Dr. Jason Schuster explains that persistent, body‑wide inflammation drives many age‑related problems. By pairing the right supplements with good diet, exercise and sleep, you can lower toxic cytokines and restore metabolic balance.
Resveratrol
Resveratrol is a polyphenol found in grapes and red wine, but clinically effective amounts require a supplement. Dr. Schuster notes it is a “very very strong anti‑inflammatory” that lowers pro‑inflammatory markers such as IL‑1, IL‑6, TNF‑α and C‑reactive protein. He takes 1 gram of powdered resveratrol daily from Renew by Science, which he recommends as the most cost‑effective format.
- Reduces circulating pro‑inflammatory cytokines
- Supports mitochondrial health alongside NMN
- Typical dose: 1 g powdered resveratrol per day
Broccoli Sprout Glucaraphin
Glucaraphin, derived from broccoli sprout extract, works together with sulforaphane to activate the NRF2 anti‑inflammatory pathway. The supplement Dr. Schuster uses already contains the necessary enzyme that normally requires mustard seed for conversion in fresh broccoli. This pathway helps turn off pro‑inflammatory signals while turning on the body’s own defenses.
- Activates NRF2, a key cellular anti‑inflammatory response
- Provides both glucaraphin and sulforaphane in bioavailable form
- Taken as directed by the manufacturer (exact dose not specified in the video)
Omega‑3 Fatty Acids
EPA and DHA make up roughly 20‑30 % of brain mass, yet modern diets high in seed and canola oils push omega‑6 levels up, crowding out these essential fats. Dr. Schuster cites literature showing omega‑3s are far more effective than any current prescription drug for cardiovascular health, and they are critical for maintaining brain function and systemic homeostasis.
- Supports heart health and reduces cardiovascular risk
- Essential for brain structure and cognitive performance
- Counteracts inflammatory effects of high omega‑6 intake
Vitamin D
According to Dr. Schuster, about 95 % of the U.S. population is deficient in vitamin D, impairing insulin sensitivity, glucose metabolism and overall immune function. He supplements with 5,000 IU daily in summer and 10,000 IU daily in winter, noting that toxicity is only a concern at extremely high intakes (60,000‑100,000 IU per day).
- Enhances insulin sensitivity and metabolic homeostasis
- Crucial for optimal immune response, especially in winter months
- Typical regimen: 5,000 IU (summer) / 10,000 IU (winter); avoid >60,000 IU/day
Magnesium
Dr. Schuster points out that roughly 70 % of Americans lack sufficient magnesium, a mineral involved in over 600 metabolic and neurophysiologic processes. He takes 800 mg daily, favoring magnesium citrate or glycinate for their high bioavailability.
- Supports muscle function and over 600 enzymatic reactions
- Citrate and glycinate forms provide the greatest absorption
- Typical dose: 800 mg per day
“Resveratrol reduces pro‑inflammatory markers while glucaraphin turns on the NRF2 anti‑inflammatory pathway, so we attack inflammation from both sides.”— Dr. Jason Schuster
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